THIS WEEK IN 30 SECONDS New analyses add evidence that tirzepatide can improve several cardiometabolic risk markers at the same time; a separate three-year analysis suggests sustained improvement in predicted cardiovascular risk; and dermatology investigators report a mix of improved inflammatory skin symptoms and more frequent cosmetic changes with larger weight loss. 1. Tirzepatide:
One of the most important questions in obesity medicine is whether losing weight with newer medications translates into better long-term cardiovascular health. An August 2026 analysis of three-year SURMOUNT-1 data provides encouraging evidence for tirzepatide – but the distinction between predicted risk and actual cardiovascular events is essential. What researchers studied SURMOUNT-1 was a randomized
When patients start tirzepatide (Zepbound) for obesity, the number on the scale is usually the most visible outcome. But obesity treatment is ultimately about health, not simply weight. A newly published analysis from the SURMOUNT clinical-trial program asks a useful question: how often do patients improve several important cardiometabolic measures at the same time? What
1. Orforglipron after Wegovy or Zepbound. ATTAIN-MAINTAIN found that patients transitioned from tirzepatide or semaglutide to oral orforglipron (Foundayo) maintained substantially more of their prior weight reduction than patients switched to placebo. A new option in the maintenance discussion. https://belite.com/orforglipron-maintenance-after-wegovy-zepbound/ 2. CagriSema vs. Zepbound. CagriSema delivered 23% average weight loss in its head-to-head trial —
1. What happens after stopping Wegovy or Zepbound? Withdrawal trials show that substantial weight regain is common after semaglutide or tirzepatide is stopped. The evidence supports planning maintenance before treatment ends rather than assuming the goal weight marks the end of care. Full article: https://belite.com/what-happens-after-stopping-wegovy-zepbound/ 2. How much muscle is lost on GLP-1 treatment? Most
You’ve spent decades knowing how your body responds to diet and exercise. Then, sometime in your mid-40s, the rules seem to change. The same eating pattern that used to keep you at a steady weight starts producing a slow, stubborn creep upward. Your waist thickens even as your total weight barely changes. Your energy is
